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| H | Espérance de Tunis | - | Al Merrikh SC | 3:0 | ||
| R | Al Merrikh SC | - | Espérance de Tunis | 1:1 | ||
| H: 23.04.2010 17:00 | R: 08.05.2010 19:00 | Sieger: Espérance de Tunis | ||||
| H | Al Ittihad Tripolis | - | Al Ahly SC | 2:0 | ||
| R | Al Ahly SC | - | Al Ittihad Tripolis | 3:0 | ||
| H: 23.04.2010 20:00 | R: 09.05.2010 19:00 | Sieger: Al Ahly SC | ||||
| H | ES Sétif | - | Zanaco FC | 1:0 | ||
| R | Zanaco FC | - | ES Sétif | 2:2 | ||
| H: 24.04.2010 20:00 | R: 08.05.2010 15:00 | Sieger: ES Sétif | ||||
| H | SuperSport United | - | Heartland FC | 1:1 | ||
| R | Heartland FC | - | SuperSport United | 3:1 | ||
| H: 24.04.2010 20:15 | R: 09.05.2010 16:00 | Sieger: Heartland FC | ||||
| H | Dynamos | - | Gaborone United | 4:1 | ||
| R | Gaborone United | - | Dynamos | 0:0 | ||
| H: 25.04.2010 13:00 | R: 08.05.2010 15:30 | Sieger: Dynamos | ||||
| H | JS Kabylie | - | Petro Atlético | 2:0 | ||
| R | Petro Atlético | - | JS Kabylie | 2:1 | ||
| H: 25.04.2010 18:00 | R: 09.05.2010 16:30 | Sieger: JS Kabylie | ||||
| H | Al Hilal Omdurman | - | Ismaily | 0:1 | ||
| R | Ismaily | - | Al Hilal Omdurman | 3:1 | ||
| H: 25.04.2010 19:00 | R: 09.05.2010 18:30 | Sieger: Ismaily | ||||
| H | Djoliba AC | - | TP Mazembe | 0:1 | ||
| R | TP Mazembe | - | Djoliba AC | 3:0 | ||
| H: 25.04.2010 19:00 | R: 09.05.2010 16:30 | Sieger: TP Mazembe | ||||
