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| H | Figueirense - SC | - | Hercílio Luz - SC | 1:0 (1:0) | ||
| R | Hercílio Luz - SC | - | Figueirense - SC | 0:0 (0:0) | ||
| H: 12.03.2022 20:30 | R: 20.03.2022 15:00 | Sieger: Figueirense - SC | ||||
| H | Marcílio Dias - SC | - | Camboriú - SC | 1:1 (1:1) | ||
| R | Camboriú - SC | - | Marcílio Dias - SC | 3:2 (2:0) | ||
| H: 12.03.2022 23:00 | R: 19.03.2022 23:00 | Sieger: Camboriú - SC | ||||
| H | Chapecoense | - | Concórdia - SC | 1:1 (1:1) | ||
| R | Concórdia - SC | - | Chapecoense | 1:1 (0:0) | ||
| H: 13.03.2022 20:00 | R: 20.03.2022 20:00 | |||||
| H | Avaí - SC | - | Brusque - SC | 1:1 (1:1) | ||
| R | Brusque - SC | - | Avaí - SC | 0:0 (0:0) | ||
| H: 13.03.2022 22:30 | R: 19.03.2022 20:30 | Sieger: Brusque - SC | ||||
