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| H | Empresa Minera Huanuni | - | Real Tomayapo | 2:1 | ||
| R | Real Tomayapo | - | Empresa Minera Huanuni | 5:0 | ||
| H: 02.12.2020 20:30 | R: 05.12.2020 20:30 | Sieger: Real Tomayapo | ||||
| H | Chaco Petrolero | - | Independiente Petrolero | 0:2 | ||
| R | Independiente Petrolero | - | Chaco Petrolero | 5:0 | ||
| H: 02.12.2020 20:30 | R: 05.12.2020 20:30 | Sieger: Independiente Petrolero | ||||
| H | Fancesa | - | Deportivo FATIC | 2:1 | ||
| R | Deportivo FATIC | - | Fancesa | 1:2 | ||
| H: 02.12.2020 20:30 | R: 05.12.2020 20:30 | Sieger: Fancesa | ||||
| H | Torre Fuerte | - | Libertad Gran Mamoré | 1:3 | ||
| R | Libertad Gran Mamoré | - | Torre Fuerte | 0:1 | ||
| H: 02.12.2020 20:30 | R: 05.12.2020 20:30 | Sieger: Libertad Gran Mamoré | ||||
| H | Cochabamba FC | - | Stormers de Potosí | 1:1 | ||
| R | Stormers de Potosí | - | Cochabamba FC | 1:1 | ||
| H: 02.12.2020 20:30 | R: 05.12.2020 20:30 | |||||
| H | Oruro Royal | - | Vaca Díez | 2:3 | ||
| R | Vaca Díez | - | Oruro Royal | 2:2 | ||
| H: 02.12.2020 21:00 | R: 05.12.2020 20:30 | Sieger: Vaca Díez | ||||
