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| 09.02.2021 | 18:00 | Cercle Brugge | - | KV Oostende | 3:1 (1:1) | |
| 20:45 | KV Kortrijk | - | Standard Liège | 5:6 (0:1, 1:1, 1:1) i.E. | ||
| 10.02.2021 | 17:00 | KAS Eupen | - | Olympic Charleroi | 5:1 (1:1) | |
| 18:00 | KRC Genk | - | Sint-Truidense VV | 1:0 (0:0) | ||
| 20:45 | Club Brugge KV | - | Royal Antwerp FC | 3:1 (0:0) | ||
| 11.02.2021 | 18:00 | K Beerschot VA | - | KV Mechelen | 0:1 (0:1) | |
| 18:00 | KAA Gent | - | Sporting Charleroi | 3:1 (0:1) | ||
| 20:45 | Union Saint-Gilloise | - | RSC Anderlecht | 0:5 (0:1) |
