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| 27.11.2012 | 20:00 | RSC Anderlecht | - | KV Mechelen | 2:0 (0:0, 0:0) n.V. | |
| 28.11.2012 | 20:00 | KVC Westerlo | - | Sint-Truidense VV | 2:4 (0:1, 2:2, 5:5) i.E. | |
| 20:00 | KAA Gent | - | Sporting Lokeren | 4:2 (0:0, 0:0, 0:0) i.E. | ||
| 20:00 | SV Zulte Waregem | - | Sporting Charleroi | 4:2 (1:1, 2:2, 2:2) i.E. | ||
| 20:00 | KV Kortrijk | - | RAEC Mons | 1:0 (0:0) | ||
| 20:30 | Waasland-Beveren | - | KV Oostende | 0:3 (0:2) | ||
| 20:45 | Club Brugge KV | - | Cercle Brugge | 0:1 (0:1) | ||
| 29.11.2012 | 20:45 | KRC Genk | - | Standard Liège | 1:0 (0:0) |
