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| 22.03.2022 | 20:05 | Flandria | - | Estudiantes de Caseros | 1:2 (0:0) | |
| 22:10 | Independiente Rivadavia | - | Instituto de Córdoba | 1:2 (1:1) | ||
| 23.03.2022 | 00:10 | Almirante Brown | - | San Martín de San Juan | 1:0 (1:0) | |
| 01:00 | Estudiantes de Río Cuarto | - | Chacarita Juniors | 2:0 (1:0) | ||
| 19:05 | Almagro | - | Defensores de Belgrano | 0:1 (0:0) | ||
| 19:30 | Villa Dálmine | - | Chaco For Ever | 0:0 (0:0) | ||
| 20:00 | Alvarado | - | Brown de Adrogué | 1:2 (0:1) | ||
| 20:00 | Deportivo Riestra | - | Gimnasia de Mendoza | 0:0 (0:0) | ||
| 20:00 | Deportivo Madryn | - | Guillermo Brown | 0:1 (0:0) | ||
| 21:05 | Nueva Chicago | - | San Martín de Tucumán | 0:0 (0:0) | ||
| 24.03.2022 | 00:00 | Temperley | - | Ramón Santamarina | 3:1 (1:1) | |
| 00:00 | Ferro Carril Oeste | - | Sacachispas | 1:1 (0:1) | ||
| 00:30 | Deportivo Morón | - | Atlético Rafaela | 2:0 (1:0) | ||
| 00:35 | Quilmes | - | Agropecuario Argentino | 1:1 (1:0) | ||
| 01:15 | Belgrano de Córdoba | - | San Telmo | 3:1 (1:0) | ||
| 01:30 | Güemes de SdE | - | All Boys | 0:2 (0:0) | ||
| 01:30 | Gimnasia de Jujuy | - | Atlanta | 1:1 (0:0) | ||
| 17.05.2022 | 20:30 | Deportivo Maipú | - | Tristan Suárez | 1:1 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 7 | 5 | 1 | 1 | 11:6 | 5 | 16 |
| 2 |
|
Guillermo Brown | 7 | 5 | 1 | 1 | 9:5 | 4 | 16 |
| 3 |
|
Brown de Adrogué | 7 | 4 | 3 | 0 | 12:6 | 6 | 15 |
| 4 |
|
San Martín de Tucumán | 7 | 4 | 2 | 1 | 9:5 | 4 | 14 |
| 5 |
|
Almirante Brown | 7 | 4 | 2 | 1 | 11:8 | 3 | 14 |
| 6 |
|
Deportivo Riestra | 7 | 3 | 4 | 0 | 5:1 | 4 | 13 |
| 7 |
|
Instituto de Córdoba | 7 | 3 | 4 | 0 | 7:4 | 3 | 13 |
| 8 |
|
All Boys | 6 | 3 | 3 | 0 | 8:4 | 4 | 12 |
| 9 |
|
Chaco For Ever | 7 | 2 | 5 | 0 | 8:5 | 3 | 11 |
| 10 |
|
Deportivo Madryn | 7 | 3 | 2 | 2 | 8:6 | 2 | 11 |
| 11 |
|
Defensores de Belgrano | 7 | 3 | 2 | 2 | 8:7 | 1 | 11 |
| 12 |
|
Deportivo Maipú | 7 | 2 | 4 | 1 | 6:6 | 0 | 10 |
| 13 |
|
Almagro | 7 | 3 | 1 | 3 | 6:7 | -1 | 10 |
| 14 |
|
Quilmes | 6 | 2 | 3 | 1 | 7:5 | 2 | 9 |
| 15 |
|
Estudiantes de Caseros | 7 | 2 | 3 | 2 | 7:7 | 0 | 9 |
|
Nueva Chicago | 7 | 2 | 3 | 2 | 7:7 | 0 | 9 | |
| 17 |
|
Gimnasia de Jujuy | 7 | 2 | 3 | 2 | 8:9 | -1 | 9 |
| 18 |
|
Estudiantes de Río Cuarto | 7 | 2 | 3 | 2 | 6:7 | -1 | 9 |
| 19 |
|
Sacachispas | 7 | 1 | 5 | 1 | 8:7 | 1 | 8 |
| 20 |
|
Independiente Rivadavia | 6 | 2 | 2 | 2 | 5:6 | -1 | 8 |
| 21 |
|
Chacarita Juniors | 7 | 2 | 2 | 3 | 7:11 | -4 | 8 |
| 22 |
|
Alvarado | 7 | 1 | 4 | 2 | 9:9 | 0 | 7 |
| 23 |
|
Temperley | 7 | 2 | 1 | 4 | 8:8 | 0 | 7 |
| 24 |
|
Atlanta | 7 | 1 | 4 | 2 | 6:6 | 0 | 7 |
|
San Martín de San Juan | 7 | 2 | 1 | 4 | 6:6 | 0 | 7 | |
| 26 |
|
Deportivo Morón | 7 | 1 | 4 | 2 | 3:3 | 0 | 7 |
| 27 |
|
Atlético Rafaela | 7 | 2 | 1 | 4 | 6:7 | -1 | 7 |
| 28 |
|
Gimnasia de Mendoza | 6 | 1 | 3 | 2 | 5:4 | 1 | 6 |
| 29 |
|
Agropecuario Argentino | 7 | 1 | 3 | 3 | 5:6 | -1 | 6 |
| 30 |
|
Ferro Carril Oeste | 6 | 1 | 3 | 2 | 4:5 | -1 | 6 |
| 31 |
|
San Telmo | 6 | 1 | 3 | 2 | 4:8 | -4 | 6 |
| 32 |
|
Tristan Suárez | 7 | 0 | 5 | 2 | 9:11 | -2 | 5 |
| 33 |
|
Ramón Santamarina | 7 | 1 | 2 | 4 | 7:10 | -3 | 5 |
| 34 |
|
Flandria | 7 | 1 | 2 | 4 | 6:11 | -5 | 5 |
| 35 |
|
Güemes de SdE | 7 | 0 | 4 | 3 | 4:9 | -5 | 4 |
| 36 |
|
Villa Dálmine | 7 | 0 | 4 | 3 | 4:12 | -8 | 4 |
| 37 |
|
Mitre de SdE | 6 | 0 | 2 | 4 | 3:8 | -5 | 2 |
| Aufstieg | |
| Playoffs | |
| Playoffs | |
| Abstieg |
