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| 17.01.2021 | 21:10 | Defensores de Belgrano | - | Instituto de Córdoba | 2:0 (1:0) | |
| 21:10 | Atlanta | - | San Martín de Tucumán | 4:1 (0:0, 2:2) i.E. | ||
| 21:10 | Gimnasia de Mendoza | - | Ferro Carril Oeste | 1:4 (0:2) | ||
| 21:10 | Deportivo Morón | - | Villa Dálmine | 2:1 (1:0) | ||
| 23:10 | Estudiantes de Caseros | - | Barracas Central | 3:2 (2:1, 2:2) i.E. | ||
| 23:15 | Tigre | - | San Martín de San Juan | 3:4 (1:1, 1:1) i.E. | ||
| 18.01.2021 | 00:00 | Deportivo Riestra | - | Temperley | 1:0 (0:0) | |
| 21:10 | Agropecuario Argentino | - | Quilmes | 0:1 (0:0) |
