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| 09.02.2016 | 16:00 | AFC Ajax | - | Sevilla FC | 3:1 (1:1) | |
| 18:00 | RSC Anderlecht | - | Arsenal FC | 2:0 (2:0) | ||
| 20:00 | Middlesbrough FC | - | Dinamo Kiev | 5:0 (2:0) | ||
| 10.02.2016 | 16:00 | RB Salzburg | - | AS Roma | 0:4 (0:3) | |
| 17:00 | 1. FK Příbram | - | CSKA Moskva | 5:4 (1:0, 2:2, 2:2) i.E. | ||
| 17:00 | FC Midtjylland | - | Atlético Madrid | 5:4 (2:2, 4:4, 4:4) i.E. | ||
| 18:00 | Celtic FC | - | Valencia CF | 3:4 (1:0, 1:1, 1:1) i.E. | ||
| 18:00 | IF Elfsborg | - | Real Madrid | 1:3 (0:0) |
