 |
 |
| Viertelfinale | ||||||
|---|---|---|---|---|---|---|
| 17.11.2021 | 16:00 | Atlas Guadalajara | - | Deportivo Toluca | 3:0 (2:0) | |
| 16:00 | UANL Tigres | - | CF América | 4:2 (3:1) | ||
| 18:30 | Mazatlán FC | - | Cruz Azul | 2:1 (1:0) | ||
| 18.11.2021 | 16:00 | Club León | - | Santos Laguna | 1:0 (0:0) | |
| 20.11.2021 | 16:00 | Deportivo Toluca | - | Atlas Guadalajara | 0:0 (0:0) | |
| 16:00 | Cruz Azul | - | Mazatlán FC | 4:1 (2:0) | ||
| 19:30 | CF América | - | UANL Tigres | 0:0 (0:0) | ||
| 21.11.2021 | 18:00 | Santos Laguna | - | Club León | 1:0 (0:0) | |
| Halbfinale | ||||||
| 24.11.2021 | 16:00 | UANL Tigres | - | Cruz Azul | 0:0 (0:0) | |
| 25.11.2021 | 16:00 | Atlas Guadalajara | - | Santos Laguna | 0:1 (0:1) | |
| 27.11.2021 | 16:00 | Cruz Azul | - | UANL Tigres | 0:0 (0:0) | |
| 28.11.2021 | 18:00 | Santos Laguna | - | Atlas Guadalajara | 0:1 (0:1) | |
| Finale | ||||||
| 02.12.2021 | 18:00 | Cruz Azul | - | Santos Laguna | 2:1 (0:0) | |
| 05.12.2021 | 18:00 | Santos Laguna | - | Cruz Azul | 3:0 (2:0) | |
