 |
 |
| Recalificación | ||||||
|---|---|---|---|---|---|---|
| 21.11.2021 | 02:00 | Santos Laguna | - | Atlético San Luis | 2:0 (0:0) | |
| 04:00 | Puebla FC | - | Deportivo Guadalajara | 6:5 (1:1, 2:2) i.E. | ||
| 22.11.2021 | 00:00 | Deportivo Toluca | - | Pumas UNAM | 1:2 (0:1) | |
| 02:15 | Cruz Azul | - | CF Monterrey | 1:4 (1:2) | ||
| Viertelfinale | ||||||
| 25.11.2021 | 02:00 | Pumas UNAM | - | CF América | 0:0 (0:0) | |
| 04:05 | CF Monterrey | - | Atlas Guadalajara | 0:0 (0:0) | ||
| 26.11.2021 | 02:00 | Puebla FC | - | Club León | 2:1 (1:1) | |
| 04:05 | Santos Laguna | - | UANL Tigres | 2:1 (2:0) | ||
| 28.11.2021 | 02:00 | CF América | - | Pumas UNAM | 1:3 (1:2) | |
| 04:05 | Atlas Guadalajara | - | CF Monterrey | 1:1 (1:0) | ||
| 29.11.2021 | 01:00 | UANL Tigres | - | Santos Laguna | 1:0 (0:0) | |
| 03:05 | Club León | - | Puebla FC | 2:0 (1:0) | ||
| Halbfinale | ||||||
| 02.12.2021 | 04:00 | UANL Tigres | - | Club León | 2:1 (0:0) | |
| 03.12.2021 | 04:00 | Pumas UNAM | - | Atlas Guadalajara | 0:1 (0:1) | |
| 05.12.2021 | 04:00 | Club León | - | UANL Tigres | 2:1 (1:1) | |
| 06.12.2021 | 02:00 | Atlas Guadalajara | - | Pumas UNAM | 0:1 (0:0) | |
| Finale | ||||||
| 10.12.2021 | 04:00 | Club León | - | Atlas Guadalajara | 3:2 (1:1) | |
| 13.12.2021 | 03:15 | Atlas Guadalajara | - | Club León | 4:3 (0:0, 1:0, 1:0) i.E. | |
